Yankees Opening Day 2025 Date. Opening day for the 2025 regular season will kick off on march 27, 2025. Major league baseball unveiled the full schedule for 2025 regular season on thursday, and the yankees will open at home against the milwaukee brewers, with opening day set for thursday, march.

Et with the new york yankees, the defending american league champions, hosting the milwaukee brewers from the nl central. *sunday night baseball begins at 7 p.m.